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A02. Measurements of soft molecular systems
Advanced techniques to observe molecules, such as time-resolved spectroscopy, single-molecule detection, and nonlinear spectroscopy are being developed dramatically based on remarkable progress of laser technology. These techniques enable us to observe structure and dynamics of soft molecular systems that have been inaccessible by any conventional techniques. A deeper understanding of the nature of soft molecular systems is one of the most important subjects for molecular science.
In A02 project, we will develop new methodologies to observe metastable structures and dynamics of molecular systems and elucidate functionally-important nature of molecular flexibility. We will study mechanisms to exhibit functions of soft molecular systems, such as supramolecules, self-assembled molecules, proteins and polypeptides, and transient structures in structure formation processes. Molecular level structures of heterogeneous systems like interfaces and their properties as fields of mass transfer and reaction are also to be elucidated in the project. We aim to accomplish these goals in collaboration with groups of theoretical and computational chemistry (A01 project) and those of molecular synthesis and transformation (A03 project).
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TOPICS |
Measurements of soft molecular systems with advanced spectroscopic techniques
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Theme
- Elucidation of mechanisms to exhibit functions of soft molecular systems based on observations of metastable structures and their dynamics
- Elucidation of structures in molecular level of heterogeneous systems like interfaces and their properties as fields of mass transfer and reaction
- Development of new methodologies to observe metastable structures and dynamics of molecular systems and elucidate functionally-important nature of molecular flexibility
Keywords
Time-Resolved Spectroscopy, Space-Resolved Spectroscopy, Nonlinear Spectroscopy, Single-Molecule Spectroscopy
Research Area
Spectroscopy, Microscopy, Biomolecular Science
Planned Research Members
Time-resolved Observation and Elucidation of Functionally-important Molecular Flexibility
Leader: |
Yasuhisa MIZUTANI |
Graduate School of Science, Osaka University, Professor |
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Haruto ISHIKAWA |
Graduate School of Science, Osaka University, Associate Professor |
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Misao MIZUNO |
Graduate School of Science, Osaka University, Assistant Professor |
Study of Complex Molecular Systems by Ultrafast and Nonlinear Spectroscopy
Leader: |
Tahei TAHARA |
Molecular Spectroscopy Laboratory RIKEN, Chief Scientist |
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Satoshi TAKEUCHI |
Molecular Spectroscopy Laboratory RIKEN, Senior Research Scientist |
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Kunihiko ISHII |
Molecular Spectroscopy Laboratory RIKEN, Senior Research Scientist |
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Shoichi YAMAGUCHI |
Graduate School of Science and Engineering, Saitama University, Professor |
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Yuki SUDO |
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Professor |
Investigation on the dynamics of protein folding by single molecule fluorescence spectroscopy
Leader: |
Satoshi TAKAHASHI |
Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Professor |
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Kiyoto KAMAGATA |
Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Assistant Professor |
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Hiroyuki OIKAWA |
Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Assistant Professor |
Structual Variety and Solvation Dynamics of Hydrogen-bonded System Studied by Gas-Phase Spectroscopy
Leader: |
Masaaki FUJII |
Institute of Innovative Research,Tokyo Institute of Technology, Professor |
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Shun-ichi ISHIUCHI |
Institute of Innovative Research, Tokyo Institute of Technology, Associate Professor |
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Mitsuhiko MIYAZAKI |
Institute of Innovative Research, Tokyo Institute of Technology, Assistant Professor |
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Haruki ISHIKAWA |
Department of Chemistry, School of Science, Kitasato University, Profesor |
Proposed Research Subjects (2016-2017)
Total Internal Reflection Raman and VSFG Spectroscopies of Solid-Liquid Interfaces
Leader: |
Taka-aki ISHIBASHI |
Divison of Chemistry, Faculty of Pure and Applied Sciences, University of Tsukuba, Professor |
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Masanari OKUNO |
Divison of Chemistry, Faculty of Pure and Applied Sciences, University of Tsukuba, Assistant Professor |
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Masato KONDOH |
Divison of Chemistry, Faculty of Pure and Applied Sciences, University of Tsukuba, Assistant Professor |
Study of Intermolecular Dynamics on the Basis of Optical Control, Spectroscopy, and Direct Imaging of Molecular Clusters
Leader: |
Kenta MIZUSE |
School of Science, Tokyo Institute of Technology, Assistant Professor |
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Yasuhiro OHSHIMA |
School of Science, Tokyo Institute of Technology, Professor |
Observation of functional membrane protein interaction by solid-state NMR
Leader: |
Izuru KAWAMURA |
Division of Materials Science and Chemical Engineering, Faculty of Engineering, Yokohama National University, Associate Professor |
Oligomeric State and Conformational Dynamics of Eubacterial Ion-Pumping Rhodopsin Studied by High-Speed AFM
Leader: |
Takayuki UCHIHASHI |
Graduate School of Science, Nagoya University, Professor |
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Mikihiro SHIBATA |
School of Mathematics and Physics, College of Science and Engineerging, Kanazawa University, Associate Professor |
Supersaturation-limited Large-scale Phase Transition of Denatured Proteins
Leader: |
Yuji GOTO |
Institute for Protein Research, Osaka University, Professor |
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Masatomo SO |
Institute for Protein Research, Osaka University, Assistant Professor |
*Until June, 2017
Development of Multi-Dimensionally Extended Vibrational Circular Dichroism for D-Amino Acid Transformation
Leader: |
Hisako SATO |
Graduated School of Science and Engineering, Ehime University, Professor |
Investigating protein behaviours in cultured human cells by paramagnetic in-cell NMR
Leader: |
Yutaka ITO |
Department of Chemistry, Tokyo Metropolitan University, Professor |
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Masaki MISHIMA |
Department of Chemistry, Tokyo Metropolitan University, Associate Professor |
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Go HIRAI |
Synthetic Organic Chemistry Laboratory, RIKEN, Senior Research Scientist |
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Hiromasa YAGI |
Quantitative Biology Center, RIKEN, Research Scientist |
Reaction Chase of a Very Small Amount of Enzyme Protein by the Droplet Collision Method
Leader: |
Takashi OGURA |
Graduate School of Life Science, University of Hyogo, Professor |
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Satoru NAKASHIMA |
Graduate School of Life Science, University of Hyogo, Adjunct Associate Professor |
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Sachiko YANAGISAWA |
Graduate School of Life Science, University of Hyogo, Associate Professor |
*Until July, 2017
Tracking of Absolute Configurations of Photo-driven Chiral Molecules by Ultrasensitive and Ultrafast Vibrational Circular Dichroism Spectroscopies
Leader: |
Akira SAKAMOTO |
College of Science and Engineering, Aoyama Gakuin University, Professor |
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Hajime OKAJIMA |
College of Science and Engineering, Aoyama Gakuin University, Assistant Professor |
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Jiro ABE |
College of Science and Engineering, Aoyama Gakuin University, Professor |
Direct Observation of Photosynthesis in Chloroplast by Near-IR Vibrational Spectroscopy in Wide Time Range
Leader: |
Tomohisa TAKAYA |
Department of Chemistry, Faculty of Science, Gakushuin University, Assistant Professor |
Reaction Dynamics at the Liquid/Solid Soft-Interfaces
Leader: |
Akira YAMAKATA |
Graduate School of Engineering, Toyota Technological Institute, Associate Professor |
High-speed single-molecule measurement of molecular motors with metallic nanoprobes
Leader: |
Ryota IINO |
Okazaki Institute for Integrative Bioscience and Institute for Molecular Science, National Institutes of Natural Sciences, Professor |
Proposed Research Subjects (2014-2015)
Study of Molecular Systems by Multi-Pump Spectroscopy
Leader: |
Masayuki YOSHIZAWA |
Graduate School of Science, Tohoku University, Professor |
Total internal reflection Raman and VSFG spectroscopies of solid-liquid interfaces
Leader: |
Taka-aki ISHIBASHI |
Division of Chemistry, Faculty of Pure and Applied Sciences, University of Tsukuba, Professor |
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Miharu EGUCHI |
National Institute for Materials Science, Senior Researcher |
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Masanari OKUNO |
Division of Chemistry, Faculty of Pure and Applied Sciences, University of Tsukuba, Assistant Professor |
High speed single-molecule measurement of conformational dynamics of molecular motors probed by gold nanorod
Leader: |
Ryota IINO |
Okazaki Institute for Integrative Bioscience, Institute for Molecular Science, Professor |
Solid-state NMR structural studies of photoreceptor membrane protein
Leader: |
Izuru KAWAMURA |
Graduate School of Engineering, Yokohama National University, Associate Professor |
Single-Molecule Manipulation and Control of Protein Conformational Dynamics using High-Speed AFM
Leader: |
Takayuki UCHIHASHI |
College of Science and Engineering, , Kanazawa University, Associate Professor |
Conformational Transition of Proteins and Their Control in Restricted Hydration Spaces Formed by Crowded Biomacromolecules
Leader: |
Hiroshi SEKIYA |
Faculty of Sciences, kyushu University, Professor |
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Kenji SAKOTA |
Faculty of Sciences, kyushu University, Assistant Professor |
Development of Novel Rapid Mixer for Analysis of Enzymatic Reaction with Picoliter Inkjet Nozzle
Leader: |
Takashi OGURA |
Graduate School of Life Science, University of Hyogo, Professor |
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Shigenori NAGATOMO |
Department of Chemistry, University of Tsukuba, Lecturer |
Observation of Structural Change Directions by Using Time-Resolved Vibrational Circular Dichroism Spectroscopy
Leader: |
Akira SAKAMOTO |
College of Science and Engineering, Aoyama Gakuin University, Professor |
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Jiro ABE |
College of Science and Engineering, Aoyama Gakuin University, Professor |
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Hajime OKAJIMA |
College of Science and Engineering, Aoyama Gakuin University, Assistant Professor |
Relaxation Dynamics of Chromophore Bound Selectively to Protein Studied by Ultrafast Near-IR Vibrational Spectroscopy
Leader: |
Tomohisa TAKAYA |
Faculty of Science, Gakushuin University, Assistant Professor |
Coherent Control of Intermolecular Vibrations in Molecular Clusters and its Applications to Intermolecular Dynamics Studies
Leader: |
Kenta MIZUSE |
Department of Chemistry, Tokyo Institute of Technology, Assistant Professor |
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Yasuhiro OHSHIMA |
Department of Chemistry, Tokyo Institute of Technology, Professor |
Super High Resolution Imaging of Soft Molecular Systems Using Non-contact Atomic Force Microscopy
Leader: |
Tomoko SHIMIZU |
Nano Characterization Unit, National Institute for Materials Science, Senior Researcher |
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