理論と実験の協奏による柔らかな分子系の機能の科学-文部科学省科学研究費補助金「新学術領域研究」領域代表者 田原太平 (平成25-29年度) やわぶん

   

A02. Measurements of soft molecular systems

  Advanced techniques to observe molecules, such as time-resolved spectroscopy, single-molecule detection, and nonlinear spectroscopy are being developed dramatically based on remarkable progress of laser technology. These techniques enable us to observe structure and dynamics of soft molecular systems that have been inaccessible by any conventional techniques. A deeper understanding of the nature of soft molecular systems is one of the most important subjects for molecular science.

  In A02 project, we will develop new methodologies to observe metastable structures and dynamics of molecular systems and elucidate functionally-important nature of molecular flexibility. We will study mechanisms to exhibit functions of soft molecular systems, such as supramolecules, self-assembled molecules, proteins and polypeptides, and transient structures in structure formation processes. Molecular level structures of heterogeneous systems like interfaces and their properties as fields of mass transfer and reaction are also to be elucidated in the project. We aim to accomplish these goals in collaboration with groups of theoretical and computational chemistry (A01 project) and those of molecular synthesis and transformation (A03 project).

TOPICS
Measurements of soft molecular systems with advanced spectroscopic techniques

Measurements of soft molecular systems with advanced spectroscopic techniques

Theme

  1. Elucidation of mechanisms to exhibit functions of soft molecular systems based on observations of metastable structures and their dynamics
  2. Elucidation of structures in molecular level of heterogeneous systems like interfaces and their properties as fields of mass transfer and reaction
  3. Development of new methodologies to observe metastable structures and dynamics of molecular systems and elucidate functionally-important nature of molecular flexibility

Keywords

Time-Resolved Spectroscopy, Space-Resolved Spectroscopy, Nonlinear Spectroscopy, Single-Molecule Spectroscopy

Research Area

Spectroscopy, Microscopy, Biomolecular Science

Planned Research Members

Time-resolved Observation and Elucidation of Functionally-important Molecular Flexibility

Leader: Yasuhisa MIZUTANI Graduate School of Science, Osaka University, Professor
Haruto ISHIKAWA Graduate School of Science, Osaka University, Associate Professor
Misao MIZUNO Graduate School of Science, Osaka University, Assistant Professor

Study of Complex Molecular Systems by Ultrafast and Nonlinear Spectroscopy

Leader: Tahei TAHARA Molecular Spectroscopy Laboratory RIKEN, Chief Scientist
Satoshi TAKEUCHI Molecular Spectroscopy Laboratory RIKEN, Senior Research Scientist
Kunihiko ISHII Molecular Spectroscopy Laboratory RIKEN, Senior Research Scientist
Shoichi YAMAGUCHI Graduate School of Science and Engineering, Saitama University, Professor
Yuki SUDO Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Professor

Investigation on the dynamics of protein folding by single molecule fluorescence spectroscopy

Leader: Satoshi TAKAHASHI Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Professor
Kiyoto KAMAGATA Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Assistant Professor
Hiroyuki OIKAWA Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Assistant Professor

Structual Variety and Solvation Dynamics of Hydrogen-bonded System Studied by Gas-Phase Spectroscopy

Leader: Masaaki FUJII Institute of Innovative Research,Tokyo Institute of Technology, Professor
Shun-ichi ISHIUCHI Institute of Innovative Research, Tokyo Institute of Technology, Associate Professor
Mitsuhiko MIYAZAKI Institute of Innovative Research, Tokyo Institute of Technology, Assistant Professor
Haruki ISHIKAWA Department of Chemistry, School of Science, Kitasato University, Profesor
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Proposed Research Subjects (2016-2017)

Total Internal Reflection Raman and VSFG Spectroscopies of Solid-Liquid Interfaces

Leader: Taka-aki ISHIBASHI Divison of Chemistry, Faculty of Pure and Applied Sciences, University of Tsukuba, Professor
Masanari OKUNO Divison of Chemistry, Faculty of Pure and Applied Sciences, University of Tsukuba, Assistant Professor
Masato KONDOH Divison of Chemistry, Faculty of Pure and Applied Sciences, University of Tsukuba, Assistant Professor

Study of Intermolecular Dynamics on the Basis of Optical Control, Spectroscopy, and Direct Imaging of Molecular Clusters

Leader: Kenta MIZUSE School of Science, Tokyo Institute of Technology, Assistant Professor
Yasuhiro OHSHIMA School of Science, Tokyo Institute of Technology, Professor

Observation of functional membrane protein interaction by solid-state NMR

Leader: Izuru KAWAMURA Division of Materials Science and Chemical Engineering, Faculty of Engineering, Yokohama National University, Associate Professor

Oligomeric State and Conformational Dynamics of Eubacterial Ion-Pumping Rhodopsin Studied by High-Speed AFM

Leader: Takayuki UCHIHASHI Graduate School of Science, Nagoya University, Professor
Mikihiro SHIBATA School of Mathematics and Physics, College of Science and Engineerging, Kanazawa University, Associate Professor

Supersaturation-limited Large-scale Phase Transition of Denatured Proteins

Leader: Yuji GOTO Institute for Protein Research, Osaka University, Professor
Masatomo SO Institute for Protein Research, Osaka University, Assistant Professor
*Until June, 2017

Development of Multi-Dimensionally Extended Vibrational Circular Dichroism for D-Amino Acid Transformation

Leader: Hisako SATO Graduated School of Science and Engineering, Ehime University, Professor

Investigating protein behaviours in cultured human cells by paramagnetic in-cell NMR

Leader: Yutaka ITO Department of Chemistry, Tokyo Metropolitan University, Professor
Masaki MISHIMA Department of Chemistry, Tokyo Metropolitan University, Associate Professor
Go HIRAI Synthetic Organic Chemistry Laboratory, RIKEN, Senior Research Scientist
Hiromasa YAGI Quantitative Biology Center, RIKEN, Research Scientist

Reaction Chase of a Very Small Amount of Enzyme Protein by the Droplet Collision Method

Leader: Takashi OGURA Graduate School of Life Science, University of Hyogo, Professor
Satoru NAKASHIMA Graduate School of Life Science, University of Hyogo, Adjunct Associate Professor
Sachiko YANAGISAWA Graduate School of Life Science, University of Hyogo, Associate Professor
*Until July, 2017

Tracking of Absolute Configurations of Photo-driven Chiral Molecules by Ultrasensitive and Ultrafast Vibrational Circular Dichroism Spectroscopies

Leader: Akira SAKAMOTO College of Science and Engineering, Aoyama Gakuin University, Professor
Hajime OKAJIMA College of Science and Engineering, Aoyama Gakuin University, Assistant Professor
Jiro ABE College of Science and Engineering, Aoyama Gakuin University, Professor

Direct Observation of Photosynthesis in Chloroplast by Near-IR Vibrational Spectroscopy in Wide Time Range

Leader: Tomohisa TAKAYA Department of Chemistry, Faculty of Science, Gakushuin University, Assistant Professor

Reaction Dynamics at the Liquid/Solid Soft-Interfaces

Leader: Akira YAMAKATA Graduate School of Engineering, Toyota Technological Institute, Associate Professor

High-speed single-molecule measurement of molecular motors with metallic nanoprobes

Leader: Ryota IINO Okazaki Institute for Integrative Bioscience and Institute for Molecular Science, National Institutes of Natural Sciences, Professor
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Proposed Research Subjects (2014-2015)

Study of Molecular Systems by Multi-Pump Spectroscopy

Leader: Masayuki YOSHIZAWA Graduate School of Science, Tohoku University, Professor

Total internal reflection Raman and VSFG spectroscopies of solid-liquid interfaces

Leader: Taka-aki ISHIBASHI Division of Chemistry, Faculty of Pure and Applied Sciences, University of Tsukuba, Professor
Miharu EGUCHI National Institute for Materials Science, Senior Researcher
Masanari OKUNO Division of Chemistry, Faculty of Pure and Applied Sciences, University of Tsukuba, Assistant Professor

High speed single-molecule measurement of conformational dynamics of molecular motors probed by gold nanorod

Leader: Ryota IINO Okazaki Institute for Integrative Bioscience, Institute for Molecular Science, Professor

Solid-state NMR structural studies of photoreceptor membrane protein

Leader: Izuru KAWAMURA Graduate School of Engineering, Yokohama National University, Associate Professor

Single-Molecule Manipulation and Control of Protein Conformational Dynamics using High-Speed AFM

Leader: Takayuki UCHIHASHI College of Science and Engineering, , Kanazawa University, Associate Professor

Conformational Transition of Proteins and Their Control in Restricted Hydration Spaces Formed by Crowded Biomacromolecules

Leader: Hiroshi SEKIYA Faculty of Sciences, kyushu University, Professor
Kenji SAKOTA Faculty of Sciences, kyushu University, Assistant Professor

Development of Novel Rapid Mixer for Analysis of Enzymatic Reaction with Picoliter Inkjet Nozzle

Leader: Takashi OGURA Graduate School of Life Science, University of Hyogo, Professor
Shigenori NAGATOMO Department of Chemistry, University of Tsukuba, Lecturer

Observation of Structural Change Directions by Using Time-Resolved Vibrational Circular Dichroism Spectroscopy

Leader: Akira SAKAMOTO College of Science and Engineering, Aoyama Gakuin University, Professor
Jiro ABE College of Science and Engineering, Aoyama Gakuin University, Professor
Hajime OKAJIMA College of Science and Engineering, Aoyama Gakuin University, Assistant Professor

Relaxation Dynamics of Chromophore Bound Selectively to Protein Studied by Ultrafast Near-IR Vibrational Spectroscopy

Leader: Tomohisa TAKAYA Faculty of Science, Gakushuin University, Assistant Professor

Coherent Control of Intermolecular Vibrations in Molecular Clusters and its Applications to Intermolecular Dynamics Studies

Leader: Kenta MIZUSE Department of Chemistry, Tokyo Institute of Technology, Assistant Professor
Yasuhiro OHSHIMA Department of Chemistry, Tokyo Institute of Technology, Professor

Super High Resolution Imaging of Soft Molecular Systems Using Non-contact Atomic Force Microscopy

Leader: Tomoko SHIMIZU Nano Characterization Unit, National Institute for Materials Science, Senior Researcher
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